March 2010

Faster, safer vaccines for a nation at risk

Faster, Safer Biodefense Vaccine Design for Department of Defense Vaccine Programs, as proposed by EpiVax, Inc. A Rhode Island Biotechnology Company http://www.EpiVax.com

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February 2010

The best animal rule is no animal rule: correlates and determinants of immunogenicity

I love the words “species neutral”. Those two words conjure up Avatar-like non-humans with alluring physiognomy that is mid point between species, a topic that is probably more interesting to most of my readers than the real topic of this short essay . . .

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Sugar or Splice - Thoughts about Tregitopes and IVIG

Those who wish to further explain the myriad properties of intravenous immunoglobulin (IVIG) would do well to bear Tregitopes in mind.  

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F is for Faster vaccines! and for Flu . . .

. . . having adequate supplies of appropriate medical countermeasures; quickly distributing those countermeasures; protecting the well through vaccines and prophylactic medications, environmental cleanup. According to the WMD report card, “the United States is seriously lacking in each of these vital capabilities”. Hence the failing grade of F.

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Science for Ransom - why we don't pay to speak

OK, we’ve made our full disclosure. We don’t pay to speak. Now . . . It’s up to you. You’ve paid to attend. You deserve it. Ask the commercial conference company for the full Monty. Ask them to put the prices on the agenda. Find out which speaker is lobbying you, rather than sharing good science.

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The Futuroscope: Does the presence of Tregitopes correlate with antibody immunogenicity?

In this very brief update, we take a look at two monoclonal antibodies, Rituximab and Ofatumumab, and we compare and contrast their predicted (and observed) immunogenicity based on T cell epitope and Tregitope content. Taking out our Immunogenicity Futuroscope, we give an A+ to the Ofatumumab antibody.

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A very GAIA idea - a globally accessible, globally relevant HIV / AIDS Vaccine

There appears to be no limit to innovative ideas at the EpiVax biotechnology company. In fact, the GAIA...

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January 2010

Update on Tregitope to members of protein immunogenicity group at FDA

I had the enormous privilege of providing an update on the Tregitope technology to a group of about 30 members of the FDA protein therapeutics group this past Friday, January 29th. The topic for discussion was “Tregitope”, a very recent discovery by EpiVax scientists that we can use a peptide (or set of peptides) to suppress immune response to a range of antigens – most notably to protein therapeutics.

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T cell-driven Vaccines: Now more than Ever

Thus – vaccines based on cell mediated immune responses, not humoral immunity, may reduce morbidity while also reducing the impact of pandemics and bioterror threats on hospitals and medical personnel. This approach promises to address the need for prompt preparedness and delivery of a safe and efficacious vaccines while accelerating the timeframe of response to virulent, emergent, or bioterror-induced infectious disease.

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We believe in health care access and vaccines

This winter, I have been working in a free health care clinic in Providence, helping line up uninsured patients for H1N1 vaccine. While working at the clinic, I remember winters past spent working, as a medical student, on a measles vaccine campaign in Zaire. . .

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