EpiVax CEO/CSO Annie De Groot and Director of Analysis Frances Terry co-presented “Engineering Better Biologics: Does Nature Know Best?” at the 2021 AAPS NBC conference May 19th 2021.

Outline: 

• Background on T cells / Immunogenicity
• EpiMatrix, JanusMatrix 
  • Epitope Prediction Overview
  • H7N9 Case Study
• Treg epitopes in Biologic Proteins
• Antibody Maturation and Treg epitopes
• Short demo of the ISPRI toolkit (Interactive Screening and Protein Reengineering Interface).

EpiVax’s discovery of regulatory T cell epitopes (also known as Tregitopes) is very relevant to both biologics and vaccines. EpiVax has developed a suite of tools that can be used to engineer proteins to include or remove T cell epitopes and help researchers design safer and more effective biologics and vaccines.

• Regulatory T cell epitopes (also known as Tregitopes) is very relevant to both biologics and vaccines.
• Antibodies naturally have regulatory T cell epitopes while pathogens have been known to introduce Tregitopes into their own sequences as a mechanism of immune escape.
• EpiVax has developed a suite of tools that can be used to engineer proteins to include or remove T cell epitopes and design safer and more effective biologics and vaccines.