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The discovery of natural regulatory T cell epitopes in the sequence of therapeutic mAbs represents a paradigm shift for protein therapeutics, allergy, autoimmunity and transplantation. These natural Treg epitopes (also known as Tregitopes) are promiscuous MHC Class II T cell epitopes located in the Fc and framework regions. At a meeting held on May 16th, 2010, the latest Tregitope research was reviewed, and protocols were refined. Members from five collaborating laboraories were present. The agenda for the meeting is presented below. 

Agenda

EpiVax 3rd Annual Tregitope Meeting

Held at: Westin Copley, Boston, Massachusetts 02116

Sunday May 16, 2010

I.               Welcome

II.              Brief Background on Tregitope (ADG)

III.            Collaborator Presentations

a.     Diabetes / OVA

University of Maryland – David Scott, Yan Su, Xin Li

Presented by Annie De Groot

b.     Gene Therapy

Children’s Hospital of Philadelphia – Katherine High, Federico Mingozzi and Danny Hui

c.       Transplantation /  MLR Studies

Brighams and Women’s – Nadar Najafian, Francesca D’Addio and Mo Sayegh

IV.            Discussion