Tired of the same old Turkey?
Even fully human antibodies can be immunogenic (see Mike Clark’s nice paper about that at the link below). It’s about time that someone came up with a new idea. So, we did. . . . tolerization is the process of introducing tolerogenic sequences into the biologic that are known to trigger expansion of regulatory T cells to promote regulatory T cell responses, downregulating anti-drug-antibodies that might occur. In a just-published paper (open access), we describe the contribution of T cell epitopes to the immunogenicity of biologics, address some of the methods that biologics developers have used to identify these T cell epitopes, and use Campath1H and 1G to illustrate the effects of humanization, de-immunization and tolerization on biologic proteins, as a special case study.
. . . Download the Recipe.
Get your copy of the article here. And, for dessert, download your (now final) copy of the “T cell “White Paper” at this link: The TCWP. And oh right – Have a wonderful Thanksgiving! — the EpiVax Crew
Clark M. Antibody humanization: a case of the ‘Emperor’s new clothes’? Immunol Today. 21(8), 397-402 (2000).
If you have a question, or wish to learn about our services, please Contact Us Here.
Thanks for reading!