- Antigen-specific tolerance induction by Tregitopes in vivo
- Immunogenic Biologics: Validation of Screening, Deimmunization and Tolerization Approaches
- In silico High Throughput Pre-clinical Determination of Monoclonal Antibody Immunogenicity
Talk: Wednesday, November 13
3:30 Progress towards Inducing Immunological Tolerance to Factor VIII
David W. Scott, Ph.D., Professor and Vice Chair, Research, Medicine, Uniformed Services, University of Health Sciences, Bethesda
Many hemophilia A patients treated with therapeutic factor VIII (FVIII) produce neutralizing antibodies to the product, thus rendering this therapy ineffective. Recently, significant progress has been made to modulate this undesirable immune response. Methods to identify immunodominant epitopes in FVIII and the generation of T cell clones against FVIII have aided this progress. Novel approaches to induce tolerance using IgG fusion proteins, nanoparticles, gene therapy and specific T regulatory cells will be discussed.
If you would like to meet at this meeting please contact Anthony Marcello at firstname.lastname@example.org.