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Tregitope Publications

 

  • Dembele M, Tao S, Massoud AH, Miah SM, Lelias S, De Groot AS, Mazer BD. Tregitopes Improve Asthma by Promoting Highly Suppressive and Antigen-Specific Tregs. Frontiers in Immunology. April 2021. doi: 10.3389/fimmu.2021.634509. Full Text

 

  • Kedzierska AE, Lorek D, Slawek A, Chelmonska-Soyta A. Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings. Scientific  Reports. June 2020. doi: 10.1038/s41598-020-66957-z. Full Text 

 

  • De Groot, A.S., Skowron, G., White, J.R. et al. Therapeutic administration of Tregitope-Human Albumin Fusion with Insulin Peptides to promote Antigen-Specific Adaptive Tolerance Induction. Scientific Reports. November 2019.  doi:10.1038/s41598-019-52331-1 Full PDF

 

  • Prangtaworn P, Chaisri U, Seesuay W, Mahasongkram K, Onlamoon N, Reamtong O, Tungtrongchitr A, Indrawattana N, Chaicumpa W, Sookrung N. Tregitope-linked Refined Allergen Vaccines for Immunotherapy in Cockroach Allergy. Scientific Reports. October 2018. doi: 10.1038/s41598-018-33680-9. Full Text

 

  • Okoniewska KM, Kedzierska AE, Okoniewski J, Slawek A, Grzymajlo K, Chelmonska-Soyta A, Grabowski T. New tregitopes inducing adaptive regulatory T cells in mice. Journal of  Physiology and Pharmacology. December 2017. PMID: 29550802 Full Text
  • Leslie Cousens, Nader Najafian, William D. Martin, Anne S. De Groot, Tregitope: Immunomodulation Powerhouse. Human Immunology. Dec 2014. doi:10.1016/j.humimm.2014.10.012 Full PDF.
  • Editorial. Anne S De Groot, Do Tregitopes have the potential to impact the current treatment landscape of autoimmune diseases? Expert Review of Clinical Immunology 2013 9:12, 1155-1157.  Full PDF.
  • Opinion. Anne S. De Groot, Leslie Cousens, Federico Mingozzi, and William Martin, Tregitope Peptides: The Active Pharmaceutical Ingredient of IVIG? Clinical and Developmental Immunology, vol. 2013, Article ID 493138, 6 pages, 2013. doi:10.1155/2013/493138,  PDF 
  • Commentary. De Groot AS, Terry F, Cousens L. and Martin W.  Beyond humanization and de-immunization: toleration as a method for reducing the immunogenicity of biologics. Expert Review of Clinical Pharmacology.  Nov 2013 https://bit.ly/BeyondHuNov13
  • Hui, DJ, Basner-Tschakarjan E., Chen Y.,  Davidson RJ, Buchlis G, Yazicioglu M, Pien, GC Finn JD Haurigot V, Tai A, Scott DW, Cousens LP, Zhou S, De Groot AD, Mingozzi F. Modulation of CD8+ T cell responses to AAV vectors with IgG-derived MHC class II epitopes. Molecular Therapy. July 2013.  https://bit.ly/AAVTregEV
  • Inaba H, Moise L, Martin W, De Groot AS, Desrosiers J, Tassone R, Buchman G, Akamizu T, De Groot LJ. Epitope Recognition in HLA-DR3 Transgenic Mice Immunized to TSH-R Protein or Peptides. Endocrinology. 2013 Jun;154(6):2234-43. doi:10.1210/en.2013-1033. Epub 2013 Apr 16. PubMed PMID: 23592747.
  • Leslie P. Cousens, Anne S. De Groot,  David W. Scott, et al. Regulatory T cell epitopes (Tregitopes) in IgG induce tolerance in vivo and lack immunogenicity per se. J. Leukocyte Biology. May 2013 https://1.usa.gov/18RQAgR
  • Leslie P. Cousens, Yan Sb, Elizabeth McClaine, Xin Li, Frances Terry, Robert Smith, Jinhee Lee, William Martin, David W. Scott Anne S. De Groot Application of IgG-derived natural Treg epitopes (IgG Tregitopes) to antigen-specific tolerance induction in a murine model of type 1 diabetes. April 2013 https://bit.ly/TregT1D https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655598/
  • Chapter. Vibha Jawa; Leslie Cousens and De Groot AS, Immunogenicity of Therapeutic Fusion proteins: Contributory Factors and Clinical Experience.Chapter in: Fusion Protein Technologies for Biopharmaceuticals: Applications and Challenges. Stefan R. Schmidt (Editor). John Wiley and Sons, Inc. March 2013. https://bit.ly/Amgen_Prospective_Tregitope_Data.
  • Cousens, Mingozzi, van der Marel, Su, Garman, Ferreira, Martin, Scott, and De Groot. Teaching tolerance: New approaches to enzyme replacement therapy for Pompe disease. Hum Vacc & Immunother. Oct 2012https://bit.ly/TregPompes
  • Cousens, Najafian, Mingozzi, Elyaman, Mazer, Moise, Messitt, Su, Sayegh, Khoury, Scott, De Groot. In vitro and in vivo studies of IgG-Derived Treg epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity. J Clin Immunol. Epub Sep 2012 https://bit.ly/TregInVivo12
  • Cousens, Tassone, Mazer, Ramachandiran, Scott, De Groot. Tregitope update: Mechanism of action parallels IVIG. Autoimmun Rev. 2012 Aug 28. [Epub ahead of print]. PMID: 22944299. https://bit.ly/TregIVIG2012
  • van der Marel S, Majowicz A, Kwikkers K, van Logtenstein R, te Velde AA, De Groot AS, Meijer SL, van Deventer SJ, Petry H, Hommes DW, Ferreira V.  Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis. World J Gastroenterol. Aug 2012. https://bit.ly/TregAAV12
  • Elyaman W, Khoury SJ, Scott DW, De Groot AS. Potential Application of Tregitopes as Immunomodulating Agents in Multiple Sclerosis. Neurol Res Int. Apr 2011. https://bit.ly/TregMS11
  • De Groot AS, Moise L, McMurry JA, Wambre E, Van Overvelt L, Moingeon P, Scott DW, Martin W. Activation of Natural Regulatory T cells by IgG Fc-derived Peptide “Tregitopes”. Blood. Oct 2008. https://bit.ly/Blood08