Guide Superior Vaccine Design
Using the proprietary iVAX™ toolkit, immunoinformatics experts at EpiVax can analyze antigen sequences for you, compiling results into a comprehensive PreVAX™ report that aims to provide an assessment of “whole protein” and “regional” immunogenic potential of antigens of interest to compare, prioritize, select and/or optimize antigen sequences during vaccine development.
This assessment can also be useful to select for the minimal, essential antigens of a pathogen responsible for eliciting robust and sustained protective immunity, while also eliminating non-essential information that could lead to the diminished protective immunity and/or immunopathology that are sometimes associated with whole organism vaccines. Combining this novel approach with best-in-class delivery technologies can enhance vaccine efficacy.
The analysis generally incorporates epitope mapping to identify immunogenic T cell epitopes, regulatory T cell epitopes (sequences cross-conserved with the human genome), and sequences conserved across multiple strains. In the final PreVAX™ Report, EpiVax summarizes these detailed findings, tailored to support your specific goals, in a comprehensive report including easy-to-understand data visualizations and expert interpretation, to aid your research and development process.