MOST RECENT PUBLICATIONS & POSTERS
Immunoinformatic risk assessment of host cell proteins during process development for biologic therapeutics. The AAPS Journal. 2023
Optimization of therapeutic antibodies for reduced self-association and non-specific binding via interpretable machine learning. Nature Biomedical Engineering. 2023.
Identification of immunodominant T cell epitopes induced by natural Zika virus infection. Frontiers in Immunology. 2023.
Immunogenicity risk assessment of synthetic peptide drugs and their impurities. Drug Discovery Today. 2023.
Comparison of predicted T cell epitopes in porcine circovirus type 2 isolates from 2017 to 2021 and selected vaccines (EpiCC analysis) confirms the global relevance of a bivalent vaccine approach. Veterinary Vaccine. 2023.
Diversity and evolution of computationally predicted T cell epitopes against human respiratory syncytial virus PLOS Computational Biology. 2023.
H1N1 G4 swine influenza T cell epitope analysis in swine and human vaccines and circulating strains uncovers potential risk to swine and humans Influenza and Other Respiratory Viruses. 2022.
Novel H7N9 influenza immunogen design enhances mobilization of seasonal influenza T cell memory in H3N2 pre-immune mice Human Vaccines & Immunotherapeutics. 2022.
Evaluation of a Human T Cell-Targeted Multi-Epitope Vaccine for Q Fever in Animal Models of Coxiella burnetii Immunity Frontiers. 2022.
Neoantigen-based personalized cancer vaccines: the emergence of precision cancer immunotherapy Expert Review of Vaccines. 2021.
Immune Tolerance-Adjusted Personalized Immunogenicity Prediction for Pompe Disease Frontiers in Immunology. 2021.
Development of a Novel Fully Functional Coagulation Factor VIII with Reduced Immunogenicity Utilizing an In silico Prediction and Deimmunization Approach Journal of Thrombosis and Haemostasis. 2021.
Self-Replicating RNAs Drive Protective Anti-tumor T Cell Responses to Neoantigen Vaccine Targets in a Combinatorial Approach Molecular Therapy. 2021.
Identification, Selection and Immune Assessment of Liver Stage CD8 T Cell Epitopes From Plasmodium falciparum Frontiers in Immunology. 2021.
Bridging Computational Vaccinology and Vaccine Development Through Systematic Identification, Characterization, and Downselection of Conserved and Variable Circumsporozoite Protein CD4 T Cell Epitopes From Diverse Plasmodium falciparum Strains Frontiers in Immunology. 2021.
Highly conserved, non-human-like, and cross-reactive SARS-CoV-2 T cell epitopes for COVID-19 vaccine design and validation npj Vaccines. 2021.
Multi-step screening of neoantigens’ HLA- and TCR-interfaces improves prediction of survival Scientific Reports. 2021.
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