EpiVax is attending the Immunogenicity Summit in Bethesda this week. Look for Leslie and Annie in person (Annie is usually at the microphone asking questions about HLA associations). We will be piloting some new slides on Epitope Networks. (For more on that, see the link to our CHO/Host Cell protein talk, which is also available on line, below).
You have time to get to the meeting, because our talk is entitled, Peptides that Act as T Regulators: Implications for Control of Immunogenicity and Application to Protein Therapeutics (a.k.a. Tregitopes) does not take place until 4 PM on Friday!
If you miss the Tregitope talk at the Immunogenicity Summit, we have provided links to recent papers that can be downloaded (see below). We’re very excited that all of the Tregitope papers are “Open Access”.Enjoy the papers and we hope to see you at the Summit!
Cousens LP, et al. In Vitro and In Vivo Studies of IgG-Derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity. J Clin Immunol. 2012
Cousens LP, Tassone R, Mazer BD, Ramachandiran V, Scott DW, De Groot AS. Tregitope Update: Mechanism of Action Parallels IVIg. Autoimmun Rev. 2012
Sander van der Marel et al. Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis. World Journal of Gastroenterology. World J Gastroenterol. 2012
Cousens LP, et al. Teaching Tolerance: New Approaches to Enzyme Replacement Therapy for Pompe Disease. Hum. Vaccin. Immunother. 2012 Oct;8 (10).
Leonard Moise, Chang Song, William D. Martin, Ryan Tassone, Anne S. De Groot and David W. Scott. HLA DR epitope de-immunization of FVIII in vitro and in vivo. Clin Immunol. 2012.
Andres H. Gutiérrez, Leonard Moise, Anne S. De Groot, Of [Hamsters] and Men: A New Perspective on Host Cell Proteins. Hum. Vaccin. Immunother. 2012 8 (9). 2012.
See here for the slides that contain our new idea about epitope networks and Treg epitopes: http://www.slideshare.net/AnnieDG/cho-hcp-immunogenicity-iciw-bailey-kellog