The annual World Vaccine and Immunotherapy Congress west coast meetings will be held on December 2-5, 2019 at the San Francisco Airport Marriott Waterfront Hotel
Dr. Lenny Moise, the Director of Vaccine Research at EpiVax will be in attendance. His talk: “Engineering vaccine antigens to recruit CD4 T cell memory for enhanced antibody responses” will be will be Tuesday December 3rd, 2019 in the Emerging Technologies track, at 3:25PM.
From this talk you can expect:
Rational vaccine antigen design approaches generally focus on antibody-based immunity using consensus sequence and structure modeling methods to produce immunogens with stabilized neutralizing epitopes. While emphasis on antibody targets is critical, attention to the quality of vaccine-induced CD4+ T cell responses is essential to ensure they support mechanisms required for protective antibody responses, including class switch recombination, affinity maturation, and B cell differentiation into long-lived plasma cells and memory cells in germinal centers. We are innovating an approach named immune engineering, that combines immunoinformatic and structure modeling methods, to engineer CD4+ T cell epitopes into protein antigens while preserving native antigen structure.